Frank-Starling Relationship
نویسندگان
چکیده
منابع مشابه
The Frank--Starling curve.
A basic property of the normal heart is that if its volume is increased, there is an increase in the strength of the contraction. The phenomenon is known as Starling's Law, and as the FrankStarling mechanism. This phenomenon is of great importance. If the heart were unable to increase its output when distended, the distension would become progressively severe. The underlying important relation ...
متن کاملCalcium, cross-bridges, and the Frank-Starling relationship.
The steep relationship between active force and length in cardiac muscle is based on a length dependence of myofilament Ca(2+) sensitivity. However, it is not muscle length but the lateral spacing between actin and myosin filaments that sets the level of Ca(2+) sensitivity, mainly through modulation of myosin-mediated activation of the thin filament.
متن کاملFrank-Starling relationship: long on importance, short on mechanism.
The Frank-Starling relationship is an intrinsic property of myocardium by which increased length (or ventricular volume) results in enhanced performance during the subsequent contraction.1–3 This relationship appears to be very important in cardiac function because increased venous return and the corresponding increase in end-diastolic volume result in greater stroke volume during the next beat...
متن کاملWho discovered the Frank-Starling mechanism?
In 1866 at Carl Ludwig's Physiological Institute at Leipzig, Elias Cyon described the influence of diastolic filling of the isolated perfused frog heart on ejection volume. A study performed at the institute of the effect of filling pressure on contraction amplitude was published in 1869 by Joseph Coats, based on a recording made by Henry P. Bowditch.
متن کاملMyosin head orientation: a structural determinant for the Frank-Starling relationship.
The cellular mechanism underlying the Frank-Starling law of the heart is myofilament length-dependent activation. The mechanism(s) whereby sarcomeres detect changes in length and translate this into increased sensitivity to activating calcium has been elusive. Small-angle X-ray diffraction studies have revealed that the intact myofilament lattice undergoes numerous structural changes upon an in...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/res.90.1.11